Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 μM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats.  It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg.
Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
Keywords: buy Gliquidone | Gliquidone ic50 | Gliquidone price | Gliquidone cost | Gliquidone solubility dmso | Gliquidone purchase | Gliquidone manufacturer | Gliquidone research buy | Gliquidone order | Gliquidone mouse | Gliquidone chemical structure | Gliquidone mw | Gliquidone molecular weight | Gliquidone datasheet | Gliquidone supplier | Gliquidone in vitro | Gliquidone cell line | Gliquidone concentration | Gliquidone nmr